The Yoburn Lab
@ St. John's University, College of Pharmacy & Allied Health Professions
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Recent Publications
  • Duttaroy, A. and Yoburn, B.C. In vivo regulation of u-opioid receptor density and gene expression in CXBK and outbred swiss webster mice. Synapse, 2000, 37:118-124. PDF 
  • Lee, S.C. and Yoburn, B.C. The effect of nimodipine on opioid antagonist-induced upregulation and supersensitivity. Pharmacology, Biochemistry and Behavior, 2000, 66: 347-351. PDF
  • Shen, J., Gomes, A.B., Gallagher, A., Stafford, K and Yoburn, B.C. The role of cAMP-dependent protein kinase (PKA) in opioid agonist-induced u-opioid receptor downregulation and tolerance in mice, Synapse, 2000, 38: 322-327. PDF
  • Stafford, K., Gomes, A.B., Shen, J and Yoburn, B.C. Mu-opioid receptor downregulation contributes to opioid tolerance in vivo, Pharmacology, Biochemistry and Behavior, 2001, 69: 233-237. PDF
  • Gomes, B.A., Shen, J., Stafford, K., Patel, M. and Yoburn B.C. Mu-Opioid receptor down-regulation and tolerance are not equally dependent upon G-protein signaling, Pharmacology, Biochemistry and Behavior, 2002, 72:273- 278. PDF
  • Patel, M. Gomes, B. Patel, C. and Yoburn, B.C. Antagonist-induced u-opioid receptor upregulation decreases G-protein receptor kinase-2 and dynamin-2 abundance in mouse spinal cord, European Journal of Pharmacology, 2002, 446:37-42.  PDF
  • Patel, M.B., Patel, C.N., Rajashekara, V. and Yoburn, B.C.  Opioid agonists differentially regulate u-opioid receptors and trafficking proteins in vivo, Molecular Pharmacology, 2002, 62:1464-1470.   PDF
  • Patel, C.N., Rajashekara, V., Patel, K., Purohit, V. and Yoburn, B.C. Chronic Opioid Antagonist Treatment Selectively Regulates Trafficking and Signaling Proteins in Mouse Spinal Cord. Synapse, 2003, 50:67–76.  PDF
  • Rajashekara, V., Patel, C. N., Patel, K., Purohit, V. and Yoburn, B. C. Chronic Opioid Antagonist Treatment Dose-Dependently Regulates u-Opioid Receptors and Trafficking Proteins In Vivo. Pharmacology, Biochemistry and Behavior, 2003, 75: 909-913. PDF
  • Yoburn, B.C., Gomes, B.A., Rajashekara, V., Patel, C. and Patel, M. Role of Gialpha2-protein in opioid tolerance and mu-opioid receptor downregulation in vivo. Synapse. 2003 47:109-16. PDF
  • Yoburn, B.C., Purohit, V., Patel, K. and Zhang, Q. Opioid agonist and antagonist treatment differentially regulates immunoreactive u-opioid receptors and dynamin-2 in vivo. European Journal of Pharmacology, 2004 498:87-96.  PDF see erratum
  • Zhang, Q., Purohit, V. and Yoburn, B.C. Continuous opioid agonist treatment dose-dependently regulates u-opioid receptors and dynamin-2 in mouse spinal cord, Synapse, 2005, 56:123-128. PDF 
  • Pawar, M., Kumar, P., Sunkaraneni, S, Sirohi, S, Walker, E.A. and Yoburn, B.C. Opioid agonist efficacy predicts the magnitude of tolerance and the regulation of μ-opioid receptors and dynamin-2, European Journal of Pharmacology, 2007, 563:92-101. PDF.
  • Sirohi, S., Kumar, P. and Yoburn, B.C. µ-Opioid Receptor Upregulation and Functional Supersensitivity are Independent of Antagonist Efficacy. Journal of Pharmacology and Experimental Therapeutics, 2007, 323:701–707. PDF
  • Sirohi, S., Dighe, S.V., Walker, E. A. and Yoburn, B.C. The analgesic efficacy of fentanyl: Relationship to tolerance and μ-opioid receptor regulation, Pharmacology Biochemistry and Behavior, 2008, 91: 115-120. PDF
  • Kumar, P., Sunkaraneni, S., Sirohi, S., Dighe, S.V., Walker, E.A. and Yoburn, B.C. Hydromorphone efficacy and treatment protocol impact on tolerance and mu-opioid receptor regulation.  European Journal of Pharmacology, 2008, 597: 39-45.  PDF
  • Dighe, S.V., Priyanka, M.A., Sirohi, S. and Yoburn, B.C.  Continuous Morphine Produces More Tolerance than Intermittent or Acute Treatment, Pharmacology Biochemistry and Behavior, 2009, 92: 537-542.  Abstract

  • Sirohi, S., Dighe, S.V., Madia, P.A. and Yoburn, B.C. The Relative Potency of Inverse Opioid Agonists and A Neutral Opioid Antagonist in Precipitated Withdrawal and Antagonism of Analgesia and Toxicity. Journal of Pharmacology and Experimental Therapeutics, 2009, 330: 513-519.  Abstract

  • Madia, P.A., Dighe, S.V.,Sirohi, S.,Walker, E. A. and Yoburn, B.C. Dosing protocol and analgesic efficacy determine opioid tolerance in the mouse, Psychopharmacology, 2009, 207: 413-422.  Abstract

 

 

 

 Last modified on February 08, 2010